关于李志强博士

jiangnan526

<p>大家好，我看有些人对李志强博士持一定怀疑态度，我觉得没有必要。</p><p>我也是一名医生，我的女朋友也有BB,所以我也来到这里，希望能为她解除痛苦少走弯路。</p><p>就我分析</p><p>1.北京武警总医院确有其人，大家可以通过其医院网站可以查询到！</p><p>总医院皮肤科负责人。 现为总医院皮肤科负责人。 </p><p>2.李志强博士除了回答问题，没有卖药的行为。</p><p>3.&nbsp;李志强博士关于小孩“<strong>我的小病号的308准分子激光跟踪治疗照片，准备每周拍一张</strong>”的帖子，以我做医生的经验，是真的。该设备昂贵，一般骗子是买不起的，如果你在小诊所小医院遇见了肯定是假的，他们只会去卖药。</p><p></p><p>我们在工作中，对上级医生是相当尊敬的，希望某些人的质疑不会影响到李博士帮助我们的热情！希望李博士能经常来看看，写写。工作太忙，委托你的研究生来也行！</p><p></p><p>我女朋友这个周末去北京了，周五晚零点的火车，白天八九点到北京，今晚一点多可以到家。和我说是想单独散散心，我没有多问，怕她伤心。但我想可能会去医院咨询一下。不知道会不会去找李博士。</p><p>上天为什么会弄出这个病来害人啊！</p><p>祝愿我的女朋友，祝愿大家都有一个美好的未来！</p>

天亮说晚安

大家都很尊敬李博士，同时也希望楼主你的女朋友这次北京之行能够达到预期的理想，加油！！！

李志强博士

<p>那位又怀疑我了？</p><p></p>

jiangnan526

<p>我看了很多帖子，很久以前的也看了。</p><p>可能是以前的帖子吧！</p><p>呵呵</p>

woaixxf

李博士是很难得的热心人。不管谁有问题他总是耐心解答。我对他的只有敬重！

天亮说晚安

<p>&nbsp;</p>[em04][em04][em04]

woxinfeixiang

<p>李博士，我今年念大二了，马上升入大三，我得BB将近十年了，今天刚看到您给众病友发的帖子，感觉您真是个热心人。</p><p>我想请教您一个问题，我是学生物的，当初报生物系也是想着能学一些BB的知识。现在我想考研，朝BB这个方向考，您能不能介绍一下该怎么找这个方向。如果考您的研究生要怎么办呢？如果您招的话，我一定全力以赴！</p><p></p>

woxinfeixiang

<p>我看我是发错地方了。</p>

huluisking

<p>我也是学生物的,现在硕2,我觉得从生物跨到医学,特别是这种专门的皮肤病理学,跨度还是大了些,就算你考上了人家也不一定要的,都是学生物的BB友,有空加QQ联系:85328771</p>

李志强博士

<p><font color="#3809f7" size="6">生物和免疫专业很好啊，我看日后攻克白癜风等自身免疫病的“黑箱”一定源于免疫和生物专业的进步。下面关于自身免疫的文章请参考：</font></p><font color="#3809f7" size="6"><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0;"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;"><font color="#000000" size="3">寻常型白癜风的“本”在哪里（自身免疫的黑箱）？</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">在临床工作中许多患者问我“白癜风能不能根治，你给我使用的药物和所谓的准分子激光能不能治本？”我常常也问自己白癜风的“本”到底在哪里？就目前的研究情况来看这两个问题还没有人能够回答。大家知道白癜风大体上可以分为寻常型和节段型两种，其中寻常型占绝大多数（</span><span lang="EN-US"><font face="Times New Roman">95</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">％）其余的</span><span lang="EN-US"><font face="Times New Roman">5</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">％为节段型，对于寻常型白癜风目前皮肤科学者大致上认同它是一种和</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">淋巴细胞相关的自身免疫性疾病是由</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">淋巴细胞攻击和杀伤皮肤黑素细胞所致，而对于节段型目前尚不知其原因（有证据表明可能和氧自由基的损害等有关）。免疫系统是人体抵御和防护外来有害微生物入侵的防御系统，但有时候这个防御系统会出现混乱，甚至会损伤自己人这时候就会发生自身免疫性疾病，最常见的</span><span lang="EN-US"><font face="Times New Roman">I</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">型糖尿病、红斑狼疮、类风湿性关节炎等等当然现在也应该包括寻常型白癜风在内。自身免疫性疾病人类虽然知道其直接原因主要是</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">淋巴细胞、抗体、补体等造成，但是导致免疫系统发生自伤的深层原因现在仍然不得而知。白癜风和其他严重危害人类健康的自身免疫性疾病糖尿病、红斑狼疮、类风湿性关节炎不同，各国政府、科研机构对其病理的研究投入相对较少。下面是美国剑桥免疫学学者撰写的有关自身免疫性疾病最新进展的提纲，包括白癜风在内的自身免疫疾病虽然和文中提到的</span><span lang="EN-US"><font face="Times New Roman">I</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">型糖尿病、红斑狼疮等不同，但是从病理学的角度看这些不同的疾病只是免疫系统杀伤的目标不同所致，因此对于我们更深入的认识白癜风有参考意义（文中并未提到白癜风，所有关于白癜风的部分是由我添加的注解）。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><p><font face="Times New Roman" color="#000000" size="3">&nbsp;</font></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">http://www.eurekalert.org/pub_releases/2007-01/wifb-cot011607.php</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">ublic release date: 21-Jan-2007</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><font size="3"><font color="#000000"><span lang="EN-US"><font face="Times New Roman">2007-1-21</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">公开发表</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">Cracking open the black box of autoimmune disease</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;"><font color="#000000" size="3">揭示自身免疫疾病的黑箱之谜</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">CAMBRIDGE, Mass. (January 21, 2007) -- Autoimmune diseases such as type 1 diabetes, lupus and rheumatoid arthritis occur when the immune system fails to regulate itself. But researchers have not known precisely where the molecular breakdowns responsible for such failures occur. Now, a team of scientists from the Whitehead Institute and the Dana-Farber Cancer Institute have identified a key set of genes that lie at the core of autoimmune disease, findings that may help scientists develop new methods for manipulating immune system activity. </font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">美国剑桥麻省</span><span lang="EN-US"><font face="Times New Roman">07-1-21</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">消息</span><span lang="EN-US"><font face="Times New Roman">----</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">自身免疫性疾病例如</span><span lang="EN-US"><font face="Times New Roman">I</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">型糖尿病、狼疮和类风湿性关节炎经常发生在免疫系统不能自我调节的时候。但研究人员还没有明确知道与这些疾病发生相关的分子故障在哪里。现在来自美国麻省</span><span lang="EN-US"><font face="Times New Roman">Whitehea</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">研究所和</span><span lang="EN-US"><font face="Times New Roman">Dana-Farber</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">癌症研究所的一组科学家鉴定了一组关键基因，它们是自身免疫性疾病的关键所在。这个发现可能帮助科学家们发展一种新的方法处理免疫系统活性。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">"This may shorten the path to new therapies for autoimmune disease," says Whitehead Member and MIT professor of biology Richard Young, senior author on the paper that will appear January 21 online in Nature. "With this new list of genes, we can now look for possible therapies with far greater precision."</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><font size="3"><font color="#000000"><span lang="EN-US"><font face="Times New Roman">Whitehead</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">实验室及美国麻省理工学院生物学教授</span><span lang="EN-US"><font face="Times New Roman">Richard Young</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">，是将要发表在</span><span lang="EN-US"><font face="Times New Roman">2007</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">年</span><span lang="EN-US"><font face="Times New Roman">1</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">月</span><span lang="EN-US"><font face="Times New Roman">21</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">刊《自然》杂志上的文章的第一作者，他说：这个研究可能缩短自身免疫疾病新的治疗方法产生的进程，因为这组基因，现在我们能够寻找更加精确的合理的治疗方法。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">The immune system is often described as a kind of military unit, a defense network that guards the body from invaders. Seen in this way, a group of white blood cells called T cells are the frontline soldiers of immune defense, engaging invading pathogens head on. </font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">免疫系统经常被描绘成象军队，一个防御网络能够保护机体免于被入侵。从这点看，一组称为</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞的血细胞处在免疫防线的第一线，防止病原体入侵。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">These T cells are commanded by a second group of cells called regulatory T cells. Regulatory T cells prevent biological "friendly fire" by ensuring that the T cells do not attack the body's own tissues. Failure of the regulatory T cells to control the frontline fighters leads to autoimmune disease. </font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">这些</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞受到第二组称为调节</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞（在我国被称为</span><span lang="EN-US"><font face="Times New Roman">Th</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞，也就是</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">辅助细胞）的细胞管理。调节</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞防止生物学上的“友军火力误伤”以确保</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞不攻击身体自身组织。调节</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞障碍不能控制第一线活力导致自身免疫疾病。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">Scientists previously discovered that regulatory T cells are themselves controlled by a master gene regulator called Foxp3. Master gene regulators bind to specific genes and control their level of activity, which in turn affects the behavior of cells. In fact, when Foxp3 stops functioning, the body can no longer produce working regulatory T cells. When this happens, the frontline T cells damage multiple organs and cause symptoms of type 1 diabetes and Crohn's disease. However, until now, scientists have barely understood how Foxp3 controls regulatory T cells because they knew almost nothing about the actual genes under Foxp3's purview. </font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">科学家们发现这些调节性</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞又受到称为</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">的主</span><span lang="EN-US"><font face="Times New Roman">(</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">导</span><span lang="EN-US"><font face="Times New Roman">)</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">基因调节因子的调控。主基因调节因子约束特定的基因并控制它们的活性水平，依次影响（这些免疫）细胞行为。实际上，当</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">停止作用，机体就不能再产生调节</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞。一旦发生这种情况，第一线的</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞就损伤多个器官并导致</span><span lang="EN-US"><font face="Times New Roman">I</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">型糖尿病</span><span lang="EN-US"><font face="Times New Roman">(T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">淋巴细胞攻击胰岛</span><span lang="EN-US"><font face="Times New Roman">B</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞</span><span lang="EN-US"><font face="Times New Roman">)</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">和</span><span lang="EN-US"><font face="Times New Roman">Crohn's</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">病（</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">淋巴细胞攻击肠壁细胞）。然而，直到现在科学家们还没有了解</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">是如何控制调节</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞的，因为他们对于处于</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">控制下的下游基因尚不清楚。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><p><font face="Times New Roman" color="#000000" size="3">&nbsp;</font></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">Researchers in Richard Young's Whitehead lab, working closely with immunologist Harald von Boehmer of the Dana-Farber Cancer Institute, used a DNA microarray technology developed by Young to scan the entire genome of T cells and locate the genes controlled by Foxp3. There were roughly 30 genes found to be directly controlled by Foxp3 and one, called Ptpn22, showed a particularly strong affinity. </font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">在</span><span lang="EN-US"><font face="Times New Roman">Richard Young's Whitehead</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">实验室的研究人员和</span><span lang="EN-US"><font face="Times New Roman">Dana-Farber</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">癌症研究所的免疫学家</span><span lang="EN-US"><font face="Times New Roman">Harald von Boehme</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">一起紧密合作，运用</span><span lang="EN-US"><font face="Times New Roman">DNA</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">微点阵技扫描整个基因组显示并定位了</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">所控制的基因。大致有</span><span lang="EN-US"><font face="Times New Roman">30</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">个基因发现受到</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">的直接调控并且有个名为</span><span lang="EN-US"><font face="Times New Roman">tpn22</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">的基因特别表示出强烈的亲和力。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">"This relation was striking because Ptpn22 is strongly associated with type 1 diabetes, rheumatoid arthritis, lupus and Graves' disease, but the gene had not been previously linked to regulatory T-cell function," says Alexander Marson, a MD/PhD student in the Young lab and lead author on the paper. "Discovering this correlation was a big moment for us. It verified that we were on the right track for identifying autoimmune related genes."</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 10.5pt; mso-char-indent-count: 1.0;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">“这个关系是引人注目的，因为</span><span lang="EN-US"><font face="Times New Roman">tpn22</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">与</span><span lang="EN-US"><font face="Times New Roman">I</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">型糖尿病、类风湿性关节炎、狼疮、</span><span lang="EN-US"><font face="Times New Roman">Graves'</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">病有很强的相关性，但是这个基因以前没有被与调节</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞的功能联系起来。”文章的第一作者</span><span lang="EN-US"><font face="Times New Roman">Young</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">实验室的</span><span lang="EN-US"><font face="Times New Roman">Alexander Marson</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">说道“发现这种联系对我们来说是个重大的时刻。它证实我们正走在鉴别自身免疫相关基因的正确道路上。”</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">The researchers still don't know exactly how Foxp3 enables regulatory T cells to prevent autoimmunity. But the list of the genes that Foxp3 targets provides an initial map of the circuitry of these cells, which is important for understanding how they control a healthy immune response. </font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0;"><font size="3"><font color="#000000"><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">研究者们还没有准确知道</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">是如何使调节</span><span lang="EN-US"><font face="Times New Roman">T</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">细胞避免自身免疫的。但是这一组</span><span lang="EN-US"><font face="Times New Roman">Foxp3</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">的靶基因提供了这些细胞的初始路线图，这对于了解它们如何控制一个正常的免疫反应是重要的。</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><font face="Times New Roman" color="#000000" size="3">"Autoimmune diseases take a tremendous toll on human health, but on a strictly molecular level, autoimmunity is a black box," says Young. "When we discover the molecular mechanisms that drive these conditions, we can migrate from treating symptoms to developing treatments for the disease itself."</font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0;"><font size="3"><font color="#000000"><span lang="EN-US"><font face="Times New Roman">Young</font></span><span style="FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;;">说“自身免疫疾病确实对人类的健康的带来巨大危害，但严格从分子水平说，自身免疫对人类来说依然是一个黑箱，当我们发现导致这些疾病的分子机制，我们能够从对症治疗转移到发展这些疾病自身的治疗方法。”</span></font></font></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US"><p><font face="Times New Roman" color="#000000" size="3">&nbsp;</font></p></span></p><p><font color="#000000"><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">寻常型白癜风的亦属于</span><span lang="EN-US" style="FONT-SIZE: 10.5pt; FONT-FAMILY: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">T</span><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">淋巴细胞相关的自身免疫疾病，某种未知的因素触发了免疫系统针对黑素细胞的攻击反应，皮肤的黑素细胞被</span><span lang="EN-US" style="FONT-SIZE: 10.5pt; FONT-FAMILY: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">T</span><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">细胞杀死后即导致白癜风的发生。白癜风和上面提到的</span><span lang="EN-US" style="FONT-SIZE: 10.5pt; FONT-FAMILY: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">I</span><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">型糖尿病、</span><span lang="EN-US" style="FONT-SIZE: 10.5pt; FONT-FAMILY: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">Crohn's</span><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">病、桥本氏甲状腺炎等等一样都属于深层原因未知的自身免疫性疾病。这些自身免疫疾病虽然互相之间没有直接的关系但推测其深层的免疫致病机理有相当的共性，对严重威胁人类健康的糖尿病、红斑狼疮全世界每年投入大量的人力物力进行研究，虽然现在仍然不能明确其原因，但是科学的进步已经让我们看到了曙光，相信这一天很快就会到来，我个人认为包括白癜风在内的自身免疫疾病会在今后的</span><span lang="EN-US" style="FONT-SIZE: 10.5pt; FONT-FAMILY: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">5</span><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">～</span><span lang="EN-US" style="FONT-SIZE: 10.5pt; FONT-FAMILY: &quot;Times New Roman&quot;,&quot;serif&quot;; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">15</span><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-ascii-font-family: &quot;Times New Roman&quot;; mso-hansi-font-family: &quot;Times New Roman&quot;; mso-bidi-font-size: 12.0pt; mso-font-kerning: 1.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">年内被人类完全认识清楚，机理清楚后将会开发出更有针对性的治疗方法，这些自身免疫疾病治疗成功时白癜风届时也会被彻底攻克。</span></font></p></font><p><font color="#3809f7" size="6"></font></p><p></p><p></p>

张敏

我是一个小女孩，我是用玫瑰精油做眼膜导致眼睛皮肤变白，去医院医生说我这是白癜风，我很不能接受，之前去了好多医院，皮炎所鼓楼医院很多医院都去了，后来去华夏白癜风医院看的，看了反而睫毛白了很多，之前只有几根，在治疗的阶段竟然白了一半，我害怕了，现在就是不乱去医院看，就是通过中药治疗，擦的药没有擦，就是把中药当药剂擦眼睛皮肤周边，李医生您说我现在到底该怎么办？我害怕病情恶化，我现在都不知道自己的病因到底在哪里？是真正身体缺少了什么还是因为化妆品导致了这样的，能尽快给我恢复吗？回复直接回复还是我自己到邮箱看？这注册的邮箱不是本人的，我自己乱写了一个邮箱，您可以直接我能看到吗？

1994

李志强博士 发表于 2007-8-13 21:39

                               
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生物和免疫专业很好啊，我看日后攻克白癜风等自身免疫病的“黑箱”一定源于免疫和生物专业的进步。下面关于 ...

学高分子材料与工程专业好不好，听说橡胶塑料之类的会加重白癜风，我很担心啊