请教李博士，维他命D基因和BB的关系这个对吗？（第四军医大的研究结果）

george007

没有找到中文的。只有下面这个。

我觉得我自己就是维他命d 造成的。08年还是07年体检的时候发现D很少，没有当回事。我的bb就在那个时候得的。
现在我每天吃5000IU，不是到够不够。10/11 年没有发展，去年冬天和现在又开始了。现在的在脸上，左边一个右边一个，好恐怖啊。

摘要：
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2012.11132.x/abstract

http://www.vitiligosupport.org/newsletters/winter2012/winter.html

Vi**in D Gene May Trigger Vitiligo In Chinese Individuals

Chinese researchers at the Fourth Military Medical University in Xi’an, China report in the British Journal of Dermatology that the vi**in D receptor (VDR) gene may be associated with vitiligo. These researchers suggest that this gene, which affects vi**in D production, may not be functioning normally in people with vitiligo and may be a factor for susceptibility of vitiligo. They hypothesized that gene variati** might be the reason for this dysfunction.

                               
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The objective of the researchers was to identify and evaluate any association between certain VDR gene variati** and vi**in D levels in those with vitiligo compared to a control group. They performed a hospital-based study of 749 patients with vitiligo and 763 matched controls, looking at four VDR gene alleles (one of 2 or more forms of a gene) and vi**in D levels to determine whether they were associated with vitiligo risk in the Chinese population.

They discovered that several specific VDR variati** among these four alleles were found more often in the control group and were associated with a lower risk of vitiligo. Two of these same variati** were mentioned as also relating to higher levels of vi**in D when compared to the variati** found more often in those with vitiligo, seeming to show a connection between increased vi**in D levels and decreased risk of vitiligo.

Higher levels (above 18.72 ng/mL) of vi**in D were associated with a significantly lower risk for vitiligo, and the risk increased with levels below 14.95 ng/mL.

The researchers said that the results suggest that VDR variati** do appear to affect VDR function and vi**in D levels, and could identify those with a predisposition to vitiligo in the Chinese population.

亦宁

等待博士周二回答吧！

liuhe

很深奥啊

520汪雅星

等博士

李志强博士

黑素细胞有维生素D的受体，平常我们治疗BB使用的外用药卡泊三醇、钙泊三醇就是维生素D3的衍生物，外用后可以刺激黑素细胞增殖和合成黑色素，就是其内在理论基础。BB的发生原因、牵扯的因素很多很多，这只是注意到的一个相关原因之一。

george007

谢谢博士