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UPCOMING Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo. During our study we found that the vitiligo-causing memory T-cells in both mouse and human skin seem to require IL-15 more than other types of T cells – which means they are more sensitive to levels of this protein. This is important because it means we might be able to selectively remove the vitiligo-causing cells without harming other important immune cells too. In the treated mice, the vitiligo-causing cells became undetectable, but the other T-cells resp**ible for fighting infection remained unharmed and present, suggesting that our antibody therapy might be safer for the immune system than first thought. Based on these results, we are working with the National Institutes of Health-funded Immune Tolerance Network (ITN) to develop a clinical trial to test this antibody treatment in human patients. We are hopeful that we can begin recruiting patients next summer.
即将到来 抗体的封锁IL-15信号有可能持久扭转白癜风。在我们的研究中我们发现白癜风记忆T细胞在老鼠和人类皮肤似乎都需要IL-15超过其他的T细胞,这说明他们都具有更敏感的蛋白质水平。 这一点很重要 因为这意味着我们可以有选择地去除导致白癜风的细胞，而不会损害其他重要的免疫细胞，在接受治疗的小鼠中，白癜风引起的细胞变得不可检测，但是其他负责抵抗感染的T细胞仍然没有受到伤害，这表明我们的抗体治疗对免疫系统来说可能比最初想象的还要安全。 基于这些结果，我们正与国立卫生研究院资助的免疫耐受网络（itn）合作，开发一项临床试验，以测试这种抗体治疗在人类患者中的效果。我们希望明年夏天开始招募病人。
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发表于 2019-10-28 11:12:37
楼主
发表于 2019-10-28 12:34:58
